Anti-K63-linkage Specific Ubiquitin Antibody [JM09-67]

HUABIO

Anti-K63-linkage Specific Ubiquitin Antibody [JM09-67]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P

Research Use Only

Monoclonal

JM09-67

1 mg/ml

Unconjugated

RPS27A

ribosomal protein S27a

CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, eS31, ubiquitin-ribosomal protein eS31 fusion protein, 40S ribosomal protein S27a, epididymis luminal protein 112, ubiquitin C, ubiquitin and ribosomal protein S27a, ubiquitin carboxyl extension protein 80, ubiquitin-40S ribosomal protein S27a, ubiquitin-CEP80

Rabbit

IgG

Polyubiquitin-B

Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. The addition of ubiquitin to a substrate protein is called ubiquitylation (or, alternatively, ubiquitination or ubiquitinylation). Ubiquitylation affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Only polyubiquitylation on defined lysines, mostly on K48 and K29, is related to degradation by the proteasome (referred to as the molecular kiss of death), while other polyubiquitylations (e.g. on K63, K11, K6 and M1) and monoubiquitylations may regulate processes such as endocytic trafficking, inflammation, translation and DNA repair.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161