Anti-KCNK18 Antibody

HUABIO

Anti-KCNK18 Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Kcnk18

potassium channel, subfamily K, member 18

Gm781, Tresk, Tresk-2, Trik, potassium channel subfamily K member 18, 2P K ion channel TRESK, TWIK-related individual K+ channel, TWIK-related spinal cord K+ channel, two-pore-domain potassium channel TRESK

Rabbit

IgG

Potassium channel subfamily K member 18

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161