Anti-KDM3B Antibody [1A8]

HUABIO

Anti-KDM3B Antibody [1A8]

2

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

1A8

1 mg/ml

Unconjugated

KDM3B

lysine demethylase 3B

5qNCA, C5orf7, DIJOS, JMJD1B, NET22, lysine-specific demethylase 3B, [histone H3]-dimethyl-L-lysine(9) demethylase 3B, jmjC domain-containing histone demethylation protein 2B, jumonji domain containing 1B, jumonji domain-containing protein 1B, lysine (K)-specific demethylase 3B, nuclear protein 5qNCA

Rabbit

IgG

Lysine-specific demethylase 3B

Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene. A multitude of publications have implicated JMJD1A as a driver of tumorigenesis in a variety of different cancers. Less evidence hints at JMJD1B and JMJD1C as potential oncogenic proteins. And there is persuasive data to suggest that JMJD1B is a tumor suppressor, especially in AML, and JMJD1A and JMJD1C may also be tumor suppressive in germ cell tumors. Tissue specificity: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.

-20°C,2°C to 8°C

41116161