Anti-KLHL15 Antibody

HUABIO

Anti-KLHL15 Antibody

7

ImmunoFluorescence, Western Blot

WB,IF-Cell,IHC-P

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

KLHL15

kelch like family member 15

HEL-S-305, XLID103, kelch-like protein 15, epididymis secretory protein Li 305, epididymis secretory sperm binding protein, kelch-like 15

Rabbit

IgG

Kelch-like protein 15

Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161