Anti-KMT3B Antibody [1B1]

HUABIO

Anti-KMT3B Antibody [1B1]

2

ImmunoFluorescence

Research Use Only

Monoclonal

1B1

1 mg/ml

Unconjugated

NSD1

nuclear receptor binding SET domain protein 1

ARA267, KMT3B, SOTOS, SOTOS1, STO, histone-lysine N-methyltransferase, H3 lysine-36 specific, H3-K36-HMTase, H4-K20-HMTase, NR-binding SET domain-containing protein, androgen receptor coactivator 267 kDa protein, androgen receptor-associated coregulator 267, androgen receptor-associated protein of 267 kDa, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, lysine N-methyltransferase 3B, nuclear receptor SET domain-containing protein 1, nuclear receptor-binding SET domain-containing protein 1

Rabbit

IgG

Histone-lysine N-methyltransferase, H3 lysine-36 specific

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

-20°C,2°C to 8°C

41116161