Anti-KRAS G12C mutant [AbAbKRAS01]

Absolute Antibody

Anti-KRAS G12C mutant [AbAbKRAS01]

9

This antibody binds the G12C mutant form of human KRAS protein. This ras protein binds GDP/GTP and possess intrinsic GTPase activity, that results in conversion of nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). This protein play

The binding reactivity of the original antibody (mouse IgG1) antibody towards mutated KRAS (G12C), VEGFA, TIGIT, HB-EGF and HSP90 was tested using ELISA. It was reported that this antibody does not cross-react with any other molecule than mutant KRAS. This antibody specifically recognized the KRAS protein in celly lysates of human lung cancer cell line A549 and human colon cancer cell line SW480 in a western blot (CN111705065).

Western Blot, ELISA

Research Use Only

Monoclonal

AbAbKRAS01

KRAS

KRAS proto-oncogene, GTPase

cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; CFC2; c-Ki-ras; c-Ki-ras2; c-Kirsten-ras protein; 'C-K-RAS; C-K-RAS; GTPase KRas; KI-RAS; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; K-Ras; K-Ras 2; K-ras p21 protein; KRAS1; KRAS2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; NS; NS3; OES; oncogene KRAS2; PR310 c-K-ras oncogene; RALD; RASK2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog

Rabbit

IgG

GTPase KRas

This chimeric rabbit IgG antibody was made using the variable domain sequences of the original mouse IgG1 format for improved compatibility with existing reagents, assays, and techniques.

Human

-20°C,2°C to 8°C

12352203