Anti-KRAS G12V [G12V-34], scFv fragment (His), ScFv,

Absolute Antibody

Anti-KRAS G12V [G12V-34], scFv fragment (His), ScFv,

9

This antibody is specific for mutated KRAS G12V.

The original format of this antibody (scFv) was screened against WT and mutated G12 and G13 KRAS and shown to specifically bind mKRAS G12V in an ELISA. The scFv format of this antibody was fused to mHALT-1 toxin and exhibited cytotoxic effects on SW-480 colorectal cancer cells with IC50 of 25.39 microg/mL, with minimal cytotoxicity effect on NHDF cells. The scFv format of this antibody was fused to enhanced GFP and used for IF (Teo et al., 2021; PMID: 33959410).

ImmunoFluorescence, ELISA, Other Application

Research Use Only

Monoclonal

G12V-34

This is a reformatted mouse scFv antibody, based on the original mouse scFv format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203