Anti-Ku70 Antibody [JM61-31]
ET1703-95
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetXRCC6
Overview
- SupplierHUABIO
- Product NameAnti-Ku70 Antibody [JM61-31]
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- Applications SupplierWB,IP,IF-Cell,IF-Tissue,IHC-P,FC
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJM61-31
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2547
- Target nameXRCC6
- Target descriptionX-ray repair cross complementing 6
- Target synonymsCTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross-complementing protein 6, 5'-dRP lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II, 70 kDa subunit, CTC box binding factor 75 kDa subunit, DNA repair protein XRCC6, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, X-ray repair complementing defective repair in Chinese hamster cells 6, lupus Ku autoantigen protein p70, thyroid autoantigen 70kD (Ku antigen), thyroid autoantigen 70kDa (Ku antigen), thyroid-lupus autoantigen p70
- HostRabbit
- IsotypeIgG
- Protein IDP12956
- Protein NameX-ray repair cross-complementing protein 6
- Scientific DescriptionThe Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (p70) and Ku-86 (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer 1 binding factor (E1BF), composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.
- ReactivityHuman
- Reactivity SupplierHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161