Anti-Lck (Phospho-Tyr505)

Applied Biological Materials

Anti-Lck (Phospho-Tyr505)

9

Lck (phospho-Tyr505) antibody detects endogenous levels of Lck only when phosphorylated at tyrosine 505.

Western Blot

Research Use Only

Polyclonal

Rabbit

IgG

Phosphorylated

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

Human, Mouse, Rat

-20°C,2°C to 8°C

12352203