Anti-Legumain Mouse mAb

PTM BIO

Anti-Legumain Mouse mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JMMR-2051

Unconjugated

Mouse

IgG

Legumain

Legumain (LGMN) is an asparaginyl endopeptidase that mediates lysosomal processing of antigen for class II MHC presentation. Under normal conditions, LGMN is mostly found in lysosomes. However, its expression level, cellular compartmentalization, and function may change under certain conditions, including cancer. In colorectal cancer, LGMN is upregulated and is found extracellularly and in the nucleus in both primary tumors and colorectal cancer cell lines. Legumain forms homodimers and may be activated by posttranslational modifications, including autoproteolytic cleavage, as it moves from one cellular compartment to another.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Human, Mouse

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203