Anti-LGR5 Antibody [SU32-04]

HUABIO

Anti-LGR5 Antibody [SU32-04]

7

ImmunoPrecipitation, Western Blot

WB,IHC-P,FC,IP

Research Use Only

Monoclonal

SU32-04

1 mg/ml

Unconjugated

LGR5

leucine rich repeat containing G protein-coupled receptor 5

FEX, GPR49, GPR67, GRP49, HG38, leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, orphan G protein-coupled receptor HG38

Rabbit

IgG

Leucine-rich repeat-containing G-protein coupled receptor 5

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67 (GPR67) is a protein that in humans is encoded by the LGR5 gene. It is a member of GPCR class A receptor proteins. R-spondin proteins are the biological ligands of LGR5. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues. LGR5 is a member of the Wnt signaling pathway. Although its ligand remains elusive, it has been shown that costimulation with R-spondin 1 and Wnt-3a induce increased internalization of LGR5. LGR5 also cointernalizes with LRP6 and FZD5 via a clathrin-dependent pathway to form a ternary complex upon Wnt ligand binding. Moreover, the rapid cointernalization of LRP6 by LGR5 induces faster rates of degradation for the former. LGR5 is crucial during embryogenesis as LGR null studies in mice incurred 100% neonatal mortality accompanied by several craniofacial distortions such as ankyloglossia and gastrointestinal dilation.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161