Anti-LRRK2 Antibody

HUABIO

Anti-LRRK2 Antibody

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Lrrk2

leucine-rich repeat kinase 2

4921513O20Rik, 9330188B09Rik, D630001M17Rik, Gm927, cI-46, leucine-rich repeat serine/threonine-protein kinase 2

Rabbit

IgG

Leucine-rich repeat serine/threonine-protein kinase 2

Parkinsons disease is a disorder of movement, cognition and emotion. It is characterized pathologically by neuronal degeneration with Lewy bodies, which are cytoplasmic inclusion bodies containing deposits of aggregated proteins. Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) cause autosomal-dominant parkinsonism, with clinical features of Parkinsons disease and with pleomorphic pathology including deposits of aggregated protein. The LRRK2 protein consists of multiple domains and belongs to the Roco family, a novel group of the Ras/GTPase superfamily. Besides the GTPase (Roc) domain, it contains a predicted kinase domain, with homology to MAP kinase kinase kinases. LRRK2 is localized in the cytoplasm and is associated with cellular membrane structures. The purified LRRK2 protein demonstrates autokinase activity.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161