Anti-MALT1 Antibody [PSH02-31]

HUABIO

Anti-MALT1 Antibody [PSH02-31]

2

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

PSH02-31

1 mg/ml

Unconjugated

MALT1

MALT1 paracaspase

IMD12, MLT, MLT1, PCASP1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT1 protease, caspase-like protein, mucosa associated lymphoid tissue lymphoma translocation gene 1, paracaspase-1

Rabbit

IgG

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.

-20°C,2°C to 8°C

41116161