Anti-Maspin Mouse mAb

PTM BIO

Anti-Maspin Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-2055

Unconjugated

Mouse

IgG

Serpin B5

Maspin is a breast tumor suppressor that is expressed in normal breast epithelium but lost in most breast cancer cell lines. While maspin is related to the serpin family of serine protease inhibitors, it may not function as a protease inhibitor. It plays an essential role in embryonic development through critical roles in cell adhesion. While the precise mechanism of maspin signaling is unclear, the tumor suppressing activity of maspin has been attributed to its ability to inhibit cell invasion/metastasis and angiogenesis, while promoting apoptosis. Nuclear translocation of active IKKalfa has been shown to repress maspin transcription and promote prostate cancer metastasis.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203