Anti-MCM2 Mouse mAb

PTM BIO

Anti-MCM2 Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF

Research Use Only

Monoclonal

JMMR-1375

Unconjugated

Mouse

IgG

DNA replication licensing factor MCM2

MCM 2-7 proteins are a family of six related proteins required for initiation and elongation of DNA replication. MCM2-7 bind together to form the heterohexameric MCM complex that is thought to act as a replicative helicase at the DNA replication fork. This complex is a key component of the pre-replication complex (pre-RC). Cdc6 and CDT1 recruit the MCM complex to the origin recognition complex (ORC) during late mitosis/early G1 phase forming the pre-RC and licensing the DNA for replication. Licensing of the chromatin permits the DNA to replicate only once per cell cycle, thereby helping to ensure that genetic alterations and malignant cell growth do not occur. Phosphorylatedrylation of the MCM2, MCM3, MCM4, and MCM6 subunits appears to regulate MCM complex activity and the initiation of DNA synthesis.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203