Anti-MCM7 Mouse mAb

PTM BIO

Anti-MCM7 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-1735

Unconjugated

Mouse

IgG

DNA replication licensing factor MCM7

MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM7 proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of MCM7 and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of MCM7 with the tumor suppressor protein RB1/RB.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203