Anti-MCU Antibody

HUABIO

Anti-MCU Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC,IF-Cell

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MCU

mitochondrial calcium uniporter

C10orf42, CCDC109A, HsMCU, calcium uniporter protein, mitochondrial, coiled-coil domain-containing protein 109A

Rabbit

IgG

Calcium uniporter protein, mitochondrial

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex. Activity is regulated by MICU1 and MICU2. At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca2+ levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a fight-or-flight response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161