anti-MDA5 (human), mAb (Hely-1)

AdipoGen Life Sciences

anti-MDA5 (human), mAb (Hely-1)

10

ImmunoPrecipitation, Western Blot, ELISA

Research Use Only

Monoclonal

Hely-1

1 mg/ml

>95%

IFIH1

interferon induced with helicase C domain 1

AGS7, Hlcd, IDDM19, IMD95, MDA-5, MDA5, RLR-2, SGMRT1, interferon-induced helicase C domain-containing protein 1, CADM-140 autoantigen, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, RIG-I-like receptor 2, RNA helicase-DEAD box protein 116, clinically amyopathic dermatomyositis autoantigen 140 kDa, helicard, helicase with 2 CARD domains, melanoma differentiation-associated gene 5, melanoma differentiation-associated protein 5, murabutide down-regulated protein

Mouse

IgG1

Interferon-induced helicase C domain-containing protein 1

Monoclonal Antibody. Recognizes human MDA5. Isotype: Mouse IgG1. Clone: Hely-1. Applications: ELISA, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation. - RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

-20°C,2°C to 8°C

12352203