Anti-MEF2A + MEF2C Antibody [JE63-26]

HUABIO

Anti-MEF2A + MEF2C Antibody [JE63-26]

2

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE63-26

1 mg/ml

Unconjugated

MEF2A

myocyte enhancer factor 2A

ADCAD1, RSRFC4, RSRFC9, mef2, myocyte-specific enhancer factor 2A, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), serum response factor-like protein 1

Rabbit

IgG

Myocyte-specific enhancer factor 2C

The protein encoded by MEF2A is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene. This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.

-20°C,2°C to 8°C

41116161