Anti-MEK1 Rabbit mAb

PTM BIO

Anti-MEK1 Rabbit mAb

5

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P, IP

Antibody

Research Use Only

Monoclonal

JRMR-10451-40

Unconjugated

Rabbit

IgG

Dual specificity mitogen-activated protein kinase kinase 1

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade and catalyze the concomitant Phosphorylatedrylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Monkey

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203