Anti-MEK4/MKK4 Mouse mAb

PTM BIO

Anti-MEK4/MKK4 Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF

Antibody

Research Use Only

Monoclonal

12478

Unconjugated

Mouse

IgG

Dual specificity mitogen-activated protein kinase kinase 4

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by Phosphorylatedrylation, but they differ in their preference for the Phosphorylatedrylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for Phosphorylatedrylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The Phosphorylatedrylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically Phosphorylatedrylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203