Anti-Mesothelin CAR-T Cells

BPS Bioscience

Anti-Mesothelin CAR-T Cells

7

Other Application

Research Use Only

MSLN

mesothelin

MPF, SMRP, mesothelin, CAK1 antigen, megakaryocyte potentiating factor, pre-pro-megakaryocyte-potentiating factor, soluble MPF mesothelin related protein

Mesothelin

The Anti-mesothelin CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-Mesothelin CAR Lentivirus (Mesothelin ScFv-CD8-4-1BB-CD3aeta; BPS Bioscience #78703). These ready-to use CAR-T cells express an anti-Mesothelin CAR consisting of the scFv (Single chain fragment variable) of anti-Mesothelin (clone P4) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3aeta signaling domains. These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. Figure 1: Construct diagram showing components of the anti-Mesothelin CAR expressed in anti-Mesothelin CAR-T cells.

Liquid Nitrogen

41116106

Human