Anti-MHC Class II Antibody [JA10-94]

HUABIO

Anti-MHC Class II Antibody [JA10-94]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application

WB,IP,IF-Cell,IF-Tissue,IHC-P

Research Use Only

Monoclonal

JA10-94

1 mg/ml

Unconjugated

HLA-DPB1

major histocompatibility complex, class II, DP beta 1

DPB1, HLA-DP, HLA-DP1B, HLA-DPB, HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, HLA-DP histocompatibility type, beta-1 subunit, MHC HLA DPB1, MHC class II HLA-DP-beta-1, MHC class II antigen DPB1

Rabbit

IgG

HLA class II histocompatibility antigen, DP beta 1 chain

Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an alpha or heavy chain and beta-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an alpha and beta chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumu-lating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

Human

Human

-20°C,2°C to 8°C

41116161