Anti-MICA + MICB Antibody

HUABIO

Anti-MICA + MICB Antibody

7

Western Blot

WB,IF-Cell,IHC-P

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MICB

MHC class I polypeptide-related sequence B

PERB11.2, MHC class I polypeptide-related sequence B, MHC class I antigen-related protein B, MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog

Rabbit

IgG

MHC class I polypeptide-related sequence B

MHC class I polypeptide-related sequence A/B (MICA/B) is a cell surface glycoprotein encoded by the MICA/B gene located within MHC locus. MICA and MICB are related to MHC class I and has similar domain structure, which is made up of external alpha1alpha2alpha3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICA/B rather functions as a stress-induced ligand for NKG2D receptor. MICA is broadly recognized by NK cells, gammadelta T cells, and CD8+ alphabeta T cells which carry NKG2D receptor on their cell surface. As a result of NKG2D-MICA engagement, effector cytolytic responses of T cells and NK cells against epithelial tumor cells expressing MICA are initiated. MICA/B are not associated with beta2-microglobulin nor binds peptides as conventional MHC class I molecules do. The heat shock stress pathway is involved in the regulation of MICA expression as transcription of MICA is regulated by promoter heat shock element.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161