Anti-MIF Antibody [JM11-64]

HUABIO

Anti-MIF Antibody [JM11-64]

7

Flow Cytometry, ImmunoPrecipitation, Western Blot

WB,IP,FC

Research Use Only

Monoclonal

JM11-64

1 mg/ml

Unconjugated

MIF

macrophage migration inhibitory factor

GIF, GLIF, MMIF, macrophage migration inhibitory factor, L-dopachrome isomerase, L-dopachrome tautomerase, epididymis secretory sperm binding protein, macrophage migration inhibitory factor (glycosylation-inhibiting factor), phenylpyruvate tautomerase

Rabbit

IgG

Macrophage migration inhibitory factor

Macrophage migration inhibitory factor, known as MIF or glycosylation-inhibiting factor, is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor alpha (TNFalpha), interleukin-1 (IL-1) and interferon-gamma (IFN-gamma). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161