Anti-MKLP1 Antibody [SY02-74]

HUABIO

Anti-MKLP1 Antibody [SY02-74]

7

ImmunoFluorescence, Western Blot

WB,IF-Cell,IF-Tissue

Research Use Only

Monoclonal

SY02-74

1 mg/ml

Unconjugated

KIF23

kinesin family member 23

CDA3, CDAIII, CDAN3, CDAN3A, CHO1, KNSL5, MKLP-1, MKLP1, kinesin-like protein KIF23, congenital dyserythropoietic anemia, type III, kinesin-like 5 (mitotic kinesin-like protein 1)

Rabbit

IgG

Kinesin-like protein KIF23

KIF23 (also known as Kinesin-6, CHO1/MKLP1, C. elegans ZEN-4 and Drosophila Pavarotti) is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms, better known as CHO1, the larger isoform and MKLP1, the smaller isoform. KIF23 is a plus-end directed motor protein expressed in mitosis, involved in the formation of the cleavage furrow in late anaphase and in cytokinesis. KIF23 is part of the centralspindlin complex that includes PRC1, Aurora B and 14-3-3 which cluster together at the spindle midzone to enable anaphase in dividing cells. In neuronal development KIF23 is involved in the transport of minus-end distal microtubules into dendrites and is expressed exclusively in cell bodies and dendrites.

Human

Human

Mouse,Rat

-20°C,2°C to 8°C

41116161