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Immunohistochemical staining of formalin fixed and paraffin embedded human lung tissue section using anti-MMP-12 rabbit monoclonal antibody (Clone RM381) at a 1:2500 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human lung tissue section using anti-MMP-12 rabbit monoclonal antibody (Clone RM381) at a 1:2500 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human lung tissue section using anti-MMP-12 rabbit monoclonal antibody (Clone RM381) at a 1:2500 dilution.

anti-MMP-12 (human), Rabbit Monoclonal (RM381)

Research Use Only
REV-31-1267-00
RevMAb Biosciences
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetMMP12
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-MMP-12 (human), Rabbit Monoclonal (RM381)
  • Delivery Days Customer
    5
  • Antibody Specificity
    This antibody reacts to human Matrix metalloproteinase-12 (MMP-12).
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM381
  • Gene ID4321
  • Target name
    MMP12
  • Target description
    matrix metallopeptidase 12
  • Target synonyms
    HME; macrophage metalloelastase; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12 (macrophage elastase); ME; MME; MMP-12
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Active MMP-12 (Macrophage metalloelastase; MME; Macrophage elastase; ME) has a broad substrate range. In addition to its activity against elastin, MMP-12 has been shown to cleave human CXC-chemokines such as CXCL1, CXCL2, CXCL3, CXCL5, and CXCL8. It also degrades collagen type IV, fibronectin, laminin, vitronectin, and certain proteoglycans. Although it seems to be mainly involved in COPD, MMP-12 has also been reported to be involved in malignant progression in colorectal, nonsmall cell lung cancer, prostate cancer, hepatocarcinoma and head and neck squamous cell carcinomas. The protease MMP12 is also involved in macrophage migration and potentially could have a crucial role in regulating the resolution of inflammation, by cleaving IFNgamma, thereby rendering the cytokine unable to signal via its receptor. - Recombinant Antibody. This antibody reacts to human Matrix metalloproteinase-12 (MMP-12). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Active MMP-12 (Macrophage metalloelastase; MME; Macrophage elastase; ME) has a broad substrate range. In addition to its activity against elastin, MMP-12 has been shown to cleave human CXC-chemokines such as CXCL1, CXCL2, CXCL3, CXCL5, and CXCL8. It also degrades collagen type IV, fibronectin, laminin, vitronectin, and certain proteoglycans. Although it seems to be mainly involved in COPD, MMP-12 has also been reported to be involved in malignant progression in colorectal, nonsmall cell lung cancer, prostate cancer, hepatocarcinoma and head and neck squamous cell carcinomas. The protease MMP12 is also involved in macrophage migration and potentially could have a crucial role in regulating the resolution of inflammation, by cleaving IFNgamma, thereby rendering the cytokine unable to signal via its receptor.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203