Anti-MOG [8.18-C5]

Absolute Antibody

Anti-MOG [8.18-C5]

7

The antibody binds specifically to MOG, recognising a conformational epitope. MOG is a transmembrane glycoprotein expressed on the surface of oligodendrocytes in the central nervous system, that plays an important role in maintaining the structure of the

This antibody was detected in white matter tracts of the central nervous system by immununohistochemistry. The antibody detected MOG by western blot analysis (Linnington et al., 1984; PMID: 6207204). The specificity of the original format of the antibody and Fab fragment was confirmed by ELISA analysis (Litzenburger et al., 1998; PMID: 9653093 and Menge et al., 2011; PMID: 22093619). This antibody was used for detection of MOG expressed on B cells by flow cytometry (Na et al., 2021; PMID: 34149706). MOG from HeLa cells were immunoprecipitated with the antibody. Immunofluorescence was performed on HeLa cells using this antibody (Boyle et al., 2007; PMID: 17573820). The antibody triggered in vivo expansion of CD4+ T cells in spleen, inguinal, and cervical lymph nodes (Kinzel et al. 2016; PMID: 27022743). The crystal structure of the Fab version of this antibody was determined in complex with MOGIgd (Breithaupt et al., 2003; PMID: 12874380).

Flow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry, Other Application

IHC; WB; IF; ELISA; FC; in vivo

Research Use Only

Monoclonal

8.18-C5

Rabbit

IgG

Myelin-oligodendrocyte glycoprotein

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Bovine, Guinea Pig, Human, Monkey, Mouse, Rat

Rat, mouse, guinea pig, cow, monkey, humans,

The original antibody was generated immunizing mice against Thy-1-depleted rat cerebellar glycoproteins.

-20°C,2°C to 8°C

12352203