Anti-MPXV A35 protein [MV129], Human IgG1, lambda

Absolute Antibody

Anti-MPXV A35 protein [MV129], Human IgG1, lambda

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This antibody binds the A35 protein of the monkeypox virus and also cross reacts with A33R protein of vaccinia virus. Mpox is an infectious disease caused by the monkeypox virus which can be transmitted to humans through physical contact with someone who

This antibody strongly reacted with MPXV A35 protein in an ELISA assay at half-maximal effective concentrations (EC50) of 0.035 microg/mL. The binding affinity of the original human IgG1 version for MPXV A35 protein was determined using BLI and was reported to be Kd = 2.19 pM. In an in vitro virus neutralization assay, this antibody exhibited a strong neutralizing activity, with an IC50 of 2.68 microg/mL. This antibody was capable of recognizing MPXV A35 protein from convalescent serum samples in a western blot (PMID: 39002567).

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

MV129

Human

IgG1

Virus

-20°C,2°C to 8°C

12352203