anti-MRPS12 antibody

Arigo Biolaboratories

anti-MRPS12 antibody

23

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MRPS12

mitochondrial ribosomal protein S12

MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12, uS12m, small ribosomal subunit protein uS12m, 28S ribosomal protein S12, mitochondrial, MRP-S12, S12mt, mitochondrial small ribosomal subunit protein uS12m

Rabbit

IgG

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5 UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]

-20°C

12352203