Bio-Connect
Immunohistochemical staining of formalin fixed and paraffin embedded human colon cancer tissues with MSH2 expression, using anti-MSH2 rabbit monoclonal antibody (Clone RM478) at a 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human colon cancer tissues with MSH2 expression, using anti-MSH2 rabbit monoclonal antibody (Clone RM478) at a 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human colon cancer tissues with MSH2 expression, using anti-MSH2 rabbit monoclonal antibody (Clone RM478) at a 1:100 dilution.

anti-MSH2 (C-Term) (human), Rabbit Monoclonal (RM478)

REV-31-1370-00
RevMAb Biosciences
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
TargetMSH2
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-MSH2 (C-Term) (human), Rabbit Monoclonal (RM478)
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM478
  • Gene ID4436
  • Target name
    MSH2
  • Target description
    mutS homolog 2
  • Target synonyms
    COCA1; DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2 transcript; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; MMRCS2; mutS homolog 2, colon cancer, nonpolyposis type 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP43246
  • Protein Name
    DNA mismatch repair protein Msh2
  • Scientific Description
    Recombinant Antibody. This antibody reacts to human DNA mismatch repair protein MSH2. Source: Rabbit. Isotype: Rabbit IgG. Immunogen: Recombinant protein within 500 amino acids of the C-terminus of human MSH2. Applications: IHC, WB. The mismatch repair (MMR) proteins are required to maintain genomic integrity in prokaryotes and eukaryotes, by correcting single mismatches and short unpaired regions, such as small insertions and deletions. In eukaryotes, three proteins are involved in mismatch recognition, MSH2, MSH3 and MSH6. The three proteins form two heterodimers MutSalpha (MSH2-MSH6) and MutSbeta (MSH2-MSH3). MutSalpha is thought to be involved primarily in the recognition and repair of base-base mismatches and small insertion/deletion loops. MutSbeta acts preferentially on insertion/deletion loops up to 12 nucleotides in length. The MSH2, MSH3, and PMS2 mismatch repair proteins are also involved in other DNA repair pathways such as single-strand annealing and homologous recombination, anti-recombination, DNA damage signaling, apoptosis, as well as site-specific mutagenesis during immunoglobin somatic hypermutation and class switch recombination. They interact with several other oncogenic targets, including ATR, BRCA1 or p53. Deficiencies in expression of DNA repair genes underlie many forms of cancer. If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage may increase mutations due to error-prone translesion synthesis and error prone repair. Elevated DNA damage may also increase epigenetic alterations due to errors during DNA repair. Such mutations and epigenetic alterations may give rise to cancer. MSH2 mutation is a commonly associated with hereditary nonpolyposis colorectal cancer (HNPCC). MSH2 mutations have also been linked to endometrial cancer and the development of endometrial carcinomas. - The mismatch repair (MMR) proteins are required to maintain genomic integrity in prokaryotes and eukaryotes, by correcting single mismatches and short unpaired regions, such as small insertions and deletions. In eukaryotes, three proteins are involved in mismatch recognition, MSH2, MSH3 and MSH6. The three proteins form two heterodimers MutSalpha (MSH2-MSH6) and MutSbeta (MSH2-MSH3). MutSalpha is thought to be involved primarily in the recognition and repair of base-base mismatches and small insertion/deletion loops. MutSbeta acts preferentially on insertion/deletion loops up to 12 nucleotides in length. The MSH2, MSH3, and PMS2 mismatch repair proteins are also involved in other DNA repair pathways such as single-strand annealing and homologous recombination, anti-recombination, DNA damage signaling, apoptosis, as well as site-specific mutagenesis during immunoglobin somatic hypermutation and class switch recombination. They interact with several other oncogenic targets, including ATR, BRCA1 or p53. Deficiencies in expression of DNA repair genes underlie many forms of cancer. If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage may increase mutations due to error-prone translesion synthesis and error prone repair. Elevated DNA damage may also increase epigenetic alterations due to errors during DNA repair. Such mutations and epigenetic alterations may give rise to cancer. MSH2 mutation is a commonly associated with hereditary nonpolyposis colorectal cancer (HNPCC). MSH2 mutations have also been linked to endometrial cancer and the development of endometrial carcinomas.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203

Related products

Lane 1: Mouse Thymus tissue lysates; Lane 2: Mouse Testis tissue lysates; Lane 3: Mouse NIH/3T3 cell lysates; Lane 4: Human Hela cell lysates; Lane 5: Human SW480 cell lysates probed with MSH2 Polyclonal Antibody, Unconjugated (bs-0758R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.
Product group Antibodies
Bioss Antibodies
ApplicationsImmunoFluorescence, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
TargetMSH2
  • SizePrice
Product group Antibodies
Assay Genie
TargetMSH2
  • SizePrice
Product group Antibodies
Biomatik
ApplicationsImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
TargetMSH2
  • SizePrice
Product group Antibodies
GeneTex
ApplicationsWestern Blot
TargetMSH2
  • SizePrice
Product group Antibodies
MedChem Express
TargetMSH2
  • SizePrice
Product group Antibodies
Cusabio
MSH2 AntibodyCSB-PA010253
ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
TargetMSH2
  • SizePrice
Anti-MSH2 Antibody
Product group Antibodies
Antibodies.com
ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
  • SizePrice
Immunohistochemistry analysis in human testis and liver tissues using AMAb91891 antibody. Corresponding MSH2 RNA-seq data are presented for the same tissues.
Product group Antibodies
Atlas Antibodies
ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
TargetMSH2
  • SizePrice
Product group Antibodies
Bethyl Laboratories
ApplicationsImmunoPrecipitation, Western Blot
TargetMSH2
  • SizePrice
Product group Antibodies
RayBiotech
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry
TargetMSH2
  • SizePrice