Anti-MyD88 Antibody [SC65-04]

HUABIO

Anti-MyD88 Antibody [SC65-04]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

SC65-04

1 mg/ml

Unconjugated

MYD88

MYD88 innate immune signal transduction adaptor

IMD68, MYD88D, WM1, myeloid differentiation primary response protein MyD88, TLR adaptor MYD88, mutant myeloid differentiation primary response 88, myeloid differentiation primary response 88, myeloid differentiation primary response gene (88)

Rabbit

IgG

Myeloid differentiation primary response protein MyD88

Interleukin-1 (IL-1)-induced activation of the NFkappaB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptor-associated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFkappaB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.

Human

Human

-20°C,2°C to 8°C

41116161