Anti-Myelin Basic Protein Antibody [JF0943]
ET1702-15
ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMBP
Overview
- SupplierHUABIO
- Product NameAnti-Myelin Basic Protein Antibody [JF0943]
- Delivery Days Customer7
- ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
- Applications SupplierWB,IHC-P,IF-Tissue
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJF0943
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4155
- Target nameMBP
- Target descriptionmyelin basic protein
- Target synonymsmyelin basic protein, Golli-MBP, myelin A1 protein, myelin membrane encephalitogenic protein
- HostRabbit
- IsotypeIgG
- Protein IDP02686
- Protein NameMyelin basic protein
- Scientific DescriptionMyelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system myelin. MBP phosphorylation at Threonine 125 is a complex regulatory process that modulates the contribution of MBP to the stability of the myelin sheath. Mitogen-activated protein kinases modulate MBP phosphorylation during myelinogenesis and in the demyelinating disease multiple sclerosis. MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus, the myelinated output fibers of the hippocampus. It is proposed that during periods of increased neuronal activity, calcium activates axonal nitric oxide synthase, which generates the intercellular messengers nitric oxide and superoxide and regulates the phosphorylation state of MBP by MAPK.
- ReactivityHuman, Mouse, Rat
- Reactivity SupplierHuman,Mouse,Rat
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161