Anti-MyoD1 Antibody [JM10-72]

HUABIO

Anti-MyoD1 Antibody [JM10-72]

7

Flow Cytometry, ImmunoPrecipitation, Western Blot

WB,IP,FC

Research Use Only

Monoclonal

JM10-72

1 mg/ml

Unconjugated

MYOD1

myogenic differentiation 1

CMYO17, CMYP17, MYF3, MYOD, MYODRIF, PUM, bHLHc1, myoblast determination protein 1, class C basic helix-loop-helix protein 1, myf-3, myogenic factor 3

Rabbit

IgG

Myoblast determination protein 1

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes MyoD, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either MyoD or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. MyoD transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. MyoD-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.

Human

Human

-20°C,2°C to 8°C

41116161