Anti-NA, Neuraminidase [NA-22], Human IgG1, lambda

Absolute Antibody

Anti-NA, Neuraminidase [NA-22], Human IgG1, lambda

9

This antibody is specific for the interface between adjacent NA monomers outside of the active site neuraminidase from influenza A.

The structure of the original version of this antibody was determined using cryo-EM and x-ray crystallography (Zhu et al., 2020; PMID:31757767) (Gilchuk et al., 2019; PMID:31757769). This antibody was used for an ELISA on the NA protein of influenza A (Gilchuk et al., 2019; PMID:31757769). The binding strength of this antibody to neuraminidase of influenza A was determined using surface plasmon resonance. This antibody was used for an egress inhibition assay on MDCK cells infected with influenza A. Here it showed its ability to inhibit egress at low concentrations (Gilchuk et al., 2019; PMID:31757769). This antibody was used for a HDX-MS study. The N9 antigen showed hydrogen-deuterium exchange in the presence of this antibody (Gilchuk et al., 2019; PMID:31757769). This antibody was used for a fetuin-based ELLA NA activity assay. Here it showed inhibition of NA (Zhu et al., 2020; PMID:31757767).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

NA-22

Human

IgG1

Virus

-20°C,2°C to 8°C

12352203