Anti-NCAPD2 Antibody [JE62-22]

HUABIO

Anti-NCAPD2 Antibody [JE62-22]

2

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE62-22

1 mg/ml

Unconjugated

NCAPD2

non-SMC condensin I complex subunit D2

CAP-D2, CNAP1, MCPH21, hCAP-D2, condensin complex subunit 1, XCAP-D2 homolog, chromosome condensation-related SMC-associated protein 1, chromosome-associated protein D2

Rabbit

IgG

Condensin complex subunit 1

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.

-20°C,2°C to 8°C

41116161