Anti-NF-M Antibody [JM11-20]

HUABIO

Anti-NF-M Antibody [JM11-20]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP

Research Use Only

Monoclonal

JM11-20

1 mg/ml

Unconjugated

NEFM

neurofilament medium chain

NEF3, NF-M, NFM, neurofilament medium polypeptide, 160 kDa neurofilament protein, neurofilament 3, neurofilament triplet M protein, neurofilament, medium polypeptide 150kDa, neurofilament-3 (150 kD medium)

Rabbit

IgG

Neurofilament medium polypeptide

Neurofilament-M (NF-M), for neurofilament medium polypeptide, a member of the intermediate filament family, is a major component of neuronal cytoskeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinsons disease, and Alzheimers disease.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161