Anti-Neisseria meningitidis group B capsular polysaccharide [HmenB3]

Absolute Antibody

Anti-Neisseria meningitidis group B capsular polysaccharide [HmenB3]

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This antibody binds to the capsular polysaccharide of both Neisseria meningitidis group B and E. coli K1. It also reacts with EV36, a nonpathogenic E. coli K-12 strain

The binding characteristics of this antibody have been assessed in flow cytometric analysis; this antibody binds to N. meningitidis group B and E. coli EV36 (Shin et al, 2001). It does not react with N. meningitidis groups A, C, and Y, and is non-autoreactive, as it does not react with human neuronal alpha(2-8) polysialic acid (Shin et al, 2001). This antibody has been used in a sandwich type ELISA to investigate the cross-reactivity of bacteriophage clones displaying the antigenic properties of serotype 6B pneumococcal capsular polysaccharide (Shin et al, 2002). In the presence of rabbit and human complement, this antibody exhibits bactericidal activity (Shin et al, 2001).

Flow Cytometry, ELISA

Research Use Only

Monoclonal

HmenB3

Mouse

IgG1

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques.

Bacteria

-20°C,2°C to 8°C

12352203