Schematic antibody structure of the recombinant antibody anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (Prod. No. AG-27B-0018PF). The single chain variable human fragment (ScFv) selected by antibody phage display technology and specific to the antige
Schematic antibody structure of the recombinant antibody anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (Prod. No. AG-27B-0018PF). The single chain variable human fragment (ScFv) selected by antibody phage display technology and specific to the antige
anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative free)
AG-27B-0018PF
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse
TargetNTN1
Overview
- SupplierAdipoGen Life Sciences
- Product Nameanti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)
- Delivery Days Customer10
- Antibody SpecificityRecognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.
- ApplicationsELISA, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2F5
- Concentration1 mg/ml
- Estimated Purity>95%
- FormulationLiquid
- Gene ID9423
- Target nameNTN1
- Target descriptionnetrin 1
- Target synonymsepididymis tissue protein Li 131P; MRMV4; netrin 1, mouse, homolog of; netrin-1; NTN1L
- HostHuman
- IsotypeIgG2
- Protein IDO95631
- Protein NameNetrin-1
- Scientific DescriptionNetrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b. - Recombinant Antibody. Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles. Species cross-reactivity: Human, Mouse. Clone: 2F5. Isotype: Human IgG2lambda. Applications: ELISA, FUNC (Blocking). Host: HEK 293 cells. Liquid. In PBS containing 10% glycerol. Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.
- ReactivityHuman, Mouse
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203