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ProductsBack/anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative free)
Schematic antibody structure of the recombinant antibody anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (Prod. No. AG-27B-0018PF). The single chain variable human fragment (ScFv) selected by antibody phage display technology and specific to the antige
Schematic antibody structure of the recombinant antibody anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (Prod. No. AG-27B-0018PF). The single chain variable human fragment (ScFv) selected by antibody phage display technology and specific to the antige
Schematic antibody structure of the recombinant antibody anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (Prod. No. AG-27B-0018PF). The single chain variable human fragment (ScFv) selected by antibody phage display technology and specific to the antige

anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative free)

Research Use Only
AG-27B-0018PF
AdipoGen Life Sciences
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse
TargetNTN1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.
  • Applications
    ELISA, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2F5
  • Concentration
    1 mg/ml
  • Estimated Purity
    >95%
  • Gene ID9423
  • Target name
    NTN1
  • Target description
    netrin 1
  • Target synonyms
    epididymis tissue protein Li 131P; MRMV4; netrin 1, mouse, homolog of; netrin-1; NTN1L
  • Host
    Human
  • Isotype
    IgG2
  • Scientific Description
    Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b. - Recombinant Antibody. Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles. Species cross-reactivity: Human, Mouse. Clone: 2F5. Isotype: Human IgG2lambda. Applications: ELISA, FUNC (Blocking). Host: HEK 293 cells. Liquid. In PBS containing 10% glycerol. Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203