Anti Neurocan (NCAN) mAb (Clone 1G2)

Cosmo Bio USA

Anti Neurocan (NCAN) mAb (Clone 1G2)

16

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

Clone 1g2

Mouse

Neurocan is a nervous tissue-unique, secretory proteoglycan that carries predominantly chondroitin sulfate side chains. Its expression gradually decreases with nervous tissue development. In the immature brain, neurocan exists in a full-length form with a 240 kDa-core glycoprotein, whereas in the mature brain it exists as proteolytic fragments of the NH2-terminal half (neurocan-N) with a 130 kDa-core glycopeptide and the COOH-terminal half (neurocan-C) with a 150 kDa-core glycopeptide. Neurocan is implicated in neural network formation and is a susceptibility factor for bipolar disorder. It is upregulated in central nervous system lesion sites and is a major component of glial scars. This antibody effectively recognizes the COOH-terminal half of rat neurocan core glycoprotein as well as the full length neurocan core glycoprotein. References: 1) Oohira, A. et al. (1994) Neuroscience. 60:145-157. PMID: 8052408. 2) Matsui, F. et al. (1994) Neurochem. Int. 25:425-431. 3) Watanabe, E. et al. (1995) Eur. J. Neurosci. 7:547-554. 4) Fukuda, T. et al. (1997) J. Comp. Neurol. 382:141-152. 5) Inatani, M. et al. (1999) Invest. Ophthalmol. Vis. Sci. 40:2350-2359.

-20°C

41116161