Anti-NF-kB1 p105/p50 Rabbit mAb

PTM BIO

Anti-NF-kB1 p105/p50 Rabbit mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JRMR-10378-12

Unconjugated

Rabbit

IgG

Nuclear factor NF-kappa-B p105 subunit

NF-kappa-B (nuclear factor kappa B subunit 1) is a widespread pleiotropic transcription factor, activated by intracellular and extracellular stimuli, such as cytokines, oxidative free radicals, ultraviolet radiation, and bacterial or viral products. The NF-kappa-B gene encodes a 105kd protein (p105), which can be co-translationally processed by the 26s proteasome to produce a 50kd protein (p50). The p105 protein is a specific transcription inhibitor of the Rel protein, and the p50 protein is the DNA binding subunit of the NF-kappa-B (NFKB1) protein complex. The two exist independently and play different roles. The activated NF-kappa-B is transported to the nucleus to stimulate the expression of genes involved in a variety of biological functions.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203