Anti-NFAT1 Antibody [JA11-08]

HUABIO

Anti-NFAT1 Antibody [JA11-08]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

JA11-08

1 mg/ml

Unconjugated

NFATC2

nuclear factor of activated T cells 2

JCOSL, NFAT1, NFATP, nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFAT pre-existing subunit, NFAT transcription complex, preexisting component, T cell transcription factor NFAT1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2, nuclear factor of activated T-cells, preexisting component, preexisting nuclear factor of activated T-cells 2

Rabbit

IgG

Nuclear factor of activated T-cells, cytoplasmic 2

The NFAT (nuclear factor of activated T cells) family of transcription factors regulates cytokine expression in T cells. Members of the family include NFATc1 (NFATc), NFATc2 (NFATp), NFATn, NFATc3 (NFAT4, NFATx) and NFATc4 (NFAT3). Recognition of antigen by the T cell receptor (TCR) eventually activates the calcium-dependent protein phosphatase calcineurin. Once activated, calcineurin stimulates the translocation of NFATc1 (cytoplasmic) from the cytoplasm to the nucleus where it associates with NFATn (nuclear). Like NFATc1, NFATc2 resides in the cytoplasm and translocates to the nucleus subsequent to activation of calcineurin. Once in the nucleus, NFATc2 synergizes with AP-1 transcription factors to initiate transcription of cytokine genes. NFATc3 and NFATc4 share 65% sequence identity with other members of the NFAT family. They are similar to NFATc2 in that they also synergize with the AP-1 family of proteins.

Human

Human

-20°C,2°C to 8°C

41116161