anti-NIK antibody

Arigo Biolaboratories

anti-NIK antibody

23

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

MAP3K14

mitogen-activated protein kinase kinase kinase 14

FTDCR1B; HS; HSNIK; mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK; serine/threonine-protein kinase NIK

Rabbit

IgG

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS, and mitogens. A serine/threonine protein kinase which mediates NF-kappaB activation by IL-1, TNFalpha, and CD95 has been identified and designated NIK (for NF-kappaB inducing kinase). NIK is an activator of IkappaB kinase alpha and beta (IKKalpha and IKKbeta). Therefore, NIK is a key molecule in the NF-kappaB signaling pathway leading to the expression of a variety of gene products in response to pro-inflammatory cytokines and bacterial products.

Human

-20°C

12352203