anti-NLRP6 (mouse), pAb (IN121)

AdipoGen Life Sciences

anti-NLRP6 (mouse), pAb (IN121)

10

Western Blot

Research Use Only

Polyclonal

1 mg/ml

>95%

Nlrp6

NLR family, pyrin domain containing 6

Avr, Nalp6, Navr, Navr/Avr, Non-AVR, Pypaf5, NACHT, LRR and PYD domains-containing protein 6, NACHT, leucine rich repeat and PYD containing 6, NACHT/LRR/pyrin domain-containing protein 6, PYRIN-containing APAF1-like protein 5, angiotensin II/vasopressin receptor, non-angiotensin-vasopressin receptor

Rabbit

IgG

NACHT, LRR and PYD domains-containing protein 6

NOD-like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD-like receptor (NLR) family, migrating at 100 kDa in western blot, acts as a cytosolic innate immune sensor that recognizes microbe-associated molecular patterns. NLRP6 recruits the adaptor apoptosis-associated speck-like protein (ASC) and the inflammatory caspase-1 or caspase-11 to form an inflammasome, which mediates the maturation and secretion of the pro-inflammatory cytokines IL-18 and IL-1beta. In intestinal epithelial cells, the NLRP6 inflammasome functions in regulating gut microbiome composition, and goblet cell function and is involved in susceptibility to gastrointestinal inflammatory, infectious and neoplastic diseases. In the gut, Nlrp6 controls microbiota, maintains epithelial integrity, and regulates metabolic diseases to modulate host defense during microbial infections, cancer protection, and regulation of neuroinflammation. Nlrp6 has also been shown to negatively regulate NF-kappaB signaling in mouse models. In Nlrp6-/- mice models, serum IL-18 levels are reduced under steady-state conditions and after dextran sulfate sodium (DSS)-induced colitis. The Nlrp6 inflammasome is activated during bacterial infections and the LTA (lipoteichoic acid) from Listeria binds Nlrp6 and activates the Nlrp6 inflammasome via ASC to regulate host defense during Gram-positive bacterial infection. Nlrp6 activates both caspase-1 and caspase-11. - Polyclonal Antibody. Recognizes mouse NLRP6 by Western blot. Source. Rabbit. Applications: WB. Liquid. In PBS containing 0.02% Proclin 300, 10% Glycerol. NOD-like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD-like receptor (NLR) family, migrating at 100 kDa in western blot, acts as a cytosolic innate immune sensor that recognizes microbe-associated molecular patterns. NLRP6 recruits the adaptor apoptosis-associated speck-like protein (ASC) and the inflammatory caspase-1 or caspase-11 to form an inflammasome, which mediates the maturation and secretion of the pro-inflammatory cytokines IL-18 and IL-1beta. In intestinal epithelial cells, the NLRP6 inflammasome functions in regulating gut microbiome composition, and goblet cell function and is involved in susceptibility to gastrointestinal inflammatory, infectious and neoplastic diseases. In the gut, Nlrp6 controls microbiota, maintains epithelial integrity, and regulates metabolic diseases to modulate host defense during microbial infections, cancer protection, and regulation of neuroinflammation. Nlrp6 has also been shown to negatively regulate NF-kappaB signaling in mouse models. In Nlrp6-/- mice models, serum IL-18 levels are reduced under steady-state conditions and after dextran sulfate sodium (DSS)-induced colitis. The Nlrp6 inflammasome is activated during bacterial infections and the LTA (lipoteichoic acid) from Listeria binds Nlrp6 and activates the Nlrp6 inflammasome via ASC to regulate host defense during Gram-positive bacterial infection. Nlrp6 activates both caspase-1 and caspase-11.

-20°C,2°C to 8°C

41116161