Anti-Norovirus GII.4 P domain [A1431], Human IgA1, kappa

Absolute Antibody

Anti-Norovirus GII.4 P domain [A1431], Human IgA1, kappa

9

This antibody recognizes conserved residues distal to the HBGA binding pocket but accessible on the assembled VLP. It binds each P domain monomer at a cleft between the P1 and P2 subdomains. Norovirus (NoVs) is one of the main pathogens causing sporadic c

This antibody showed broad blockade towards to all known historical GII.4 strains from 1987 onwards and neutralized the pandemic GII.P16-GII.4 Sydney strain. This antibody is also capable of blocking the VLP binding to histoblood group antigens (HBGAs). Structure revealed conserved epitopes, which were occluded on the virion or partially exposed, allowing for broad blockade with neutralizing activity. The HBGA blocking assay was used to characterize A1431 against a panel of pandemic norovirus GII.4 strains. ELISA was used to determine the binding specificity of the antibody for GII.4c VLP (PMID: 31216462).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

A1431

Human

IgA1

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Virus

-20°C,2°C to 8°C

12352203