Anti-NQO2 Antibody [SC06-68]

HUABIO

Anti-NQO2 Antibody [SC06-68]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

SC06-68

1 mg/ml

Unconjugated

NQO2

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

DHQV, DIA6, NMOR2, QR2, ribosyldihydronicotinamide dehydrogenase [quinone], N-ribosyldihydronicotinamide:quinone reductase 2, NAD(P)H dehydrogenase, quinone 2, NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2, NAD(P)H quinone dehydrogenase 2, NRH:quinone oxidoreductase 2, quinone reductase 2, ribosyldihydronicotinamide dehydrogenase

Rabbit

IgG

Ribosyldihydronicotinamide dehydrogenase [quinone]

NAD(P)H dehydrogenase, quinone 2, also known as QR2, is a protein that in humans is encoded by the NQO2 gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions of quinones. Its mechanism of reduction is through a ping-pong mechanism involving its FAD cofactor. Initially in a reductive phase NQO2 binds to reduced dihydronicotinamide riboside (NRH) electron donor, and mediates a hydride transfer from NRH to FAD. Then, in an oxidative phase, NQO2 binds to its quinone substrate and reduces the quinone to a dihydroquinone. Besides the two catalytic FAD, NQO2 also has two zinc ions. It is not clear whether the metal has a catalytic role. NQO2 is a homodimer. NQO2 can be inhibited by resveratrol. One of QR2s binding sites responds to 2-iodomelatonin, and has been referred to as MT3.

Human

Human

Mouse,Rat

-20°C,2°C to 8°C

41116161