Anti-nuclear proliferation marker [JC1]

Absolute Antibody

Anti-nuclear proliferation marker [JC1]

7

This antibody might be used in determining the rate of proliferation in cancer cells. During immunohistochemical stainings, JC1 antibody has been demonstrated to recognise a nuclear marker specific for proliferating cells (both normal and tumour) and distinct from Ki67 (Garrido et al. 1992). Importantly, the advantage of this antibody is that it does not present any additional cytoplasmic labelling in squamous or other cells (as it is the case with Ki67) (Garrido et al., 1992). Furthermore, JC1 antibody was shown to work in Western blot analysis labelling two bands in a sample derived from IM-9 cell lysates (Garrido et al., 1992). The bands were, again, different than those for Ki67, what presents an opportunity of utilising JC1 antibody as an independent and parallel clinical assessment of proliferation next to Ki67.

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

Research Use Only

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203