Anti Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) mAb (Clone 1B1F10)

Cosmo Bio USA

Anti Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) mAb (Clone 1B1F10)

16

Research Use Only

UniProt Summary Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5-YCAAGGYC-3 and 5-RRAGGTCA-3 are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. References 1) Shima Y, et al: Mol. Endocrinol. (2008)22:1633-1646 2) Yokoyama C, et al: HYBRIDOMA (2009)28(2):113-119*

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