Anti-Nucleolin Antibody [JE65-71]

HUABIO

Anti-Nucleolin Antibody [JE65-71]

2

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE65-71

1 mg/ml

Unconjugated

NCL

nucleolin

C23, Nsr1, nucleolin

Rabbit

IgG

Nucleolin

Nucleolin is a protein that in humans is encoded by the NCL gene. Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5-UUAGGG-3 repeats more tightly than the telomeric single-stranded DNA 5-TTAGGG-3 repeats. Midkine and pleiotrophin bind to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection. Nucleolin at the cell surface is the receptor for the Respiratory Syncytial Virus (RSV) fusion protein. Interference with the nucleolin - RSV fusion protein interaction has been shown to be therapeutic against RSV infection in cell cultures and animal models.

-20°C,2°C to 8°C

41116161