Anti-Nucleophosmin [NA24]

Absolute Antibody

Anti-Nucleophosmin [NA24]

9

This antibody is specific towards nucleophasmin which is a widely expressed phosphorylated protein involved in various processes, such as ribosome assebly and transport, cell proliferation, protein chaperoning and centrosome duplication. Aberrations invol

Mutations associated with nucleophasmin are present in varous conditions and this antibody has proven useful in different experiments investigating their molecular underpinnings. One group used NE24 antibody to perform immunohistochemical staining confirming that anaplastic large-cell lymphoma involves expression of mutated NPM-ALK fusion (Cordell et al., 1999). Finally, alterations of nucleophasmin expression were found in many cancers where this antibody might be utilised to analyse them. For example, Gimenez and colleagues (2010) performed immunohistochemical stainings and Western blot analyses to demonstrate aberrations in nucleophasmin expression in brain cancer.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

NA24

NPM1

nucleophosmin 1

B23; NPM; nucleolar protein NO38; nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin/nucleoplasmin family, member 1; testicular tissue protein Li 128

Mouse

IgG1

Nucleophosmin

Human

-20°C,2°C to 8°C

12352203